Your First 12 Weeks on Weight Loss Medication: A Clinical Guide to What to Expect
Your First 12 Weeks on Weight Loss Medication: A Clinical Guide to What to Expect The first 12 weeks on GLP-1 weight loss medication are clinically the most important and often the most challenging part of the treatment journey. This is the period during which the dose is gradually increased, the body is adapting to […]
Understanding Weight Regain: Why It Happens and the Evidence for Long-Term Management
Understanding Weight Regain: Why It Happens and the Evidence for Long-Term Management Weight regain after weight loss is one of the most frustrating and misunderstood aspects of obesity management. It is widely attributed to loss of motivation or return to old habits, an interpretation that is both clinically inaccurate and unhelpful. The evidence demonstrates clearly […]
Weight Loss and Type 2 Diabetes: The Clinical Evidence for Remission
Weight Loss and Type 2 Diabetes: The Clinical Evidence for Remission Type 2 diabetes is commonly described to patients as a progressive, lifelong condition that requires escalating medication over time. For a significant proportion of patients, this is not the full clinical picture. Robust evidence from randomised controlled trials demonstrates that meaningful weight loss, achieved […]
Managing Side Effects of Weight Loss Medication: What to Expect and What to Do
Managing Side Effects of Weight Loss Medication: What to Expect and What to Do The gastrointestinal side effects of GLP-1 receptor agonists are the most common reason patients reduce their dose prematurely or discontinue treatment before reaching their therapeutic weight loss goal. At Curelo Care, clinical support includes proactive guidance on side effect management because […]
Semaglutide vs Tirzepatide: What the Clinical Trial Evidence Actually Shows
Semaglutide vs Tirzepatide: What the Clinical Trial Evidence Actually Shows Semaglutide (Wegovy) and tirzepatide (Mounjaro) are currently the two most effective licensed weight management medications available in the UK. Patients researching their options frequently want a direct comparison, and the clinical trial data provides a clear and evidence-based answer. This guide explains the trial evidence […]
How GLP-1 Medications Work: A Clinical Overview
How GLP-1 Medications Work: A Clinical Overview GLP-1 receptor agonists are currently the most effective pharmacological treatments for obesity and overweight available in the UK. Understanding how they work at a clinical level helps patients make informed decisions about treatment, set realistic expectations for how their body will respond, and understand why certain side effects […]
The Science Behind Appetite: Why Hunger Is Not a Willpower Problem
The Science Behind Appetite: Why Hunger Is Not a Willpower Problem One of the most clinically important and personally liberating things a patient can understand before starting a weight management programme is that persistent hunger and difficulty maintaining weight loss are not character flaws or failures of motivation. They are the predictable, physiologically driven consequences […]
Understanding BMI and Setting Realistic Weight Loss Goals
Understanding BMI and Setting Realistic Weight Loss Goals Body mass index is the most widely used screening measure for excess weight in UK clinical practice, and it is the primary eligibility criterion for GLP-1 weight loss medication. But BMI has significant limitations that every patient should understand before using it as their sole measure of […]